565761
γ-Secretase Inhibitor IV
The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
γ-Secretase Inhibitor IV, 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
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About This Item
Empirical Formula (Hill Notation):
C25H26N2O3
Molecular Weight:
402.49
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
Biochem/physiol Actions
Cell permeable: yes
ED50 = 2.6 µM for Aβx-40
Primary Target
Aβx-40
Aβx-40
Product does not compete with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
2-Naphthoyl-Val-Phe-CHO
Green, K.N., et al. 2002. J. Physiol.541.3, 1013.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA96, 11049.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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