565763
γ-Secretase Inhibitor VI
The γ-Secretase Inhibitor VI, also referenced under CAS 287196-57-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
γ-Secretase Inhibitor VI, 1-(S)- endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide, 1-(S)-endo-N-(1,3,3)-Trimethylbicyclo[2.2.1]hept-2-yl)-4-fluorophenyl Sulfonamide
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About This Item
Empirical Formula (Hill Notation):
C16H22FNO2S
CAS Number:
Molecular Weight:
311.41
MDL number:
NACRES:
NA.54
UNSPSC Code:
12352200
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
A potent, cell-permeable inhibitor of γ-secretase that blocks the formation of Aβ42 (IC50 = 1.8 µM). Treatment of HEK293 cells with γ-secretase inhibitor VI results in an increase in β-secretase-cleaved, APP fragments and secreted APPSα, but no change in secreted APPSβ, indicating a specific inhibition of γ-secretase activity.
Cell permeable. Potently inhibits Aβ42 production (IC50 = 1.8 µM). Treatment of HEK293 cells with this inhibitor results in β-Secretase-cleaved APP fragments and secreted APPα, but no change in secreted APPsβ is observed indicating specific inhibition of γ-secretase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Aβ₄₂ production
Aβ₄₂ production
Product does not compete with ATP.
Reversible: no
Target IC50: 1.8 µM against Aβ42 production
Preparation Note
Following reconstitution, aliquot and freeze at (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Rishton, G.M., et al. 2000. J. Med. Chem.43, 2297.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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