565777
γ-Secretase Inhibitor XVI
The γ-Secretase Inhibitor XVI, also referenced under CAS 208255-51-0, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
γ-Secretase Inhibitor XVI, DAPM, N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine Methyl Ester
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About This Item
Empirical Formula (Hill Notation):
C20H20F2N2O4
CAS Number:
Molecular Weight:
390.38
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
potency
10 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 2 mg/mL
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C20H20F2N2O4/c1-12(23-17(25)10-13-8-15(21)11-16(22)9-13)19(26)24-18(20(27)28-2)14-6-4-3-5-7-14/h3-9,11-12,18H,10H2,1-2H3,(H,23,25)(H,24,26)/t12-,18-/m0/s1
InChI key
XAPDRNSTUYCSQC-SGTLLEGYSA-N
General description
A cell-permeable γ-secretase inhibitor that inhibits Aβ secretion (IC50 ~10 nM) by 7PA2 cells (CHO cell line stably transfected with APP751 containing V717F familial Alzheimer′s disease mutation) in a dose-dependent manner. Also exhibits anti-aggregation properties by selectively blocking Aβ dimer and trimer formation and subsequently preventing early Aβ oligomerization.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
γ-secretase Aβ₄₀ in 7PA2 cells
γ-secretase Aβ₄₀ in 7PA2 cells
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Walsh, D.M., et al. 2002. Nature 416, 535.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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