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Merck

566321

Sirtinol

InSolution, ≥97%, inhibitor of sirtuin class of histone deacetylase (HDAC) activity

Synonym(s):

InSolution Sirtinol, 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide, Sir Two Inhibitor Naphthol, SIRT1 Inhibitor I, SIRT1/2 Inhibitor I, SIRT2 Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C26H22N2O2
Molecular Weight:
394.47
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

Key Documents

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assay

≥97% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
ySir2
Product does not compete with ATP.
Reversible: no
Target IC50: 48 µM, 131 µM and 58 µM for ySir2, hSIRT1 and hSIRT2, respectively

Disclaimer

Toxicity: Irritant (B)

General description

A cell-permeable 2-hydroxy-1-napthaldehyde derivative that acts as a specific and a direct inhibitor of sirtuin class of histone deacetylase (HDAC) activity. Does not affect human HDAC1. Reported to block Sir2p transcriptional silencing activity in vivo (IC50 = 25 µM) and NAD-dependent HDAC activity in purified recombinant yeast Sir2p and human SIRT2 in vitro (IC50 = 68 µM and 38 µM, respectively).

Other Notes

Mai, A., et al. 2005. J. Med. Chem.48, 7789.
Grozinger, C.M., et al. 2001. J. Biol. Chem.276, 38837.

Packaging

Packaged under inert gas

Physical form

A 10 mM (1 mg/254 µl) solution of Sirtinol (Cat. No. 566320) in DMSO.

Preparation Note

Following initial thaw, aliquot and refrigerate (4°C).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

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Yi-Fan Lin et al.
iScience, 24(10), 103118-103118 (2021-10-09)
The mitochondrial unfolded protein response (UPRmt) is an organellar stress signaling pathway that functions to detect and restore disruption of mitochondrial proteostasis. The UPRmt is involved in a wide range of physiological and disease conditions, including aging, stem cell maintenance

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