Skip to Content
Merck

566326

SIRT2 Inhibitor, Inactive Control, AGK7

The SIRT2 Inhibitor, Inactive Control, AGK7, also referenced under CAS 304896-21-7, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

SIRT2 Inhibitor, Inactive Control, AGK7, SIRT2 Inhibitor I, Inactive Control

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C23H13Cl2N3O2
CAS Number:
304896-21-7
Molecular Weight:
434.27
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

InChI key

WRDKBSLEHFRKGG-UHFFFAOYSA-N

InChI

1S/C23H13Cl2N3O2/c24-16-6-8-19(25)18(12-16)21-9-7-17(30-21)11-15(13-26)23(29)28-20-5-1-3-14-4-2-10-27-22(14)20/h1-12H,(H,28,29)

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

General description

A cell-permeable structural isomer of SIRT2 Inhibitor, AGK2 (Cat. No. 566324) that selectively inhibits sirtuin 3 over sirtuins 1 and 2 (IC50 = >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2, respectively) and poorly affects both α-synuclein-mediated toxicity and α-Syn aggregation in α-Syn-H4 cells.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Sirtuin 3
Product does not compete with ATP.
Reversible: no
Target IC50: >5 µM, >50 µM and >50 µM for SIRT3, SIRT1 and SIRT2

Packaging

Packaged under inert gas

Other Notes

Outerio, T.F., et al. 2007. Science317, 516.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service