566327
SIRT1/2 Inhibitor VII
The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII
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About This Item
Empirical Formula (Hill Notation):
C15H10N2O2S
CAS Number:
Molecular Weight:
282.32
UNSPSC Code:
12352200
Assay:
≥95% (NMR)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (NMR)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white
solubility
DMSO: 3 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC50 = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD+-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Uciechowska, U., et al. 2008. ChemMedChem3, 1965.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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