Key Documents
567021
Simvastatin Sodium Salt
HMG-CoA reductase inhibitor, (Beige solid)
Synonym(s):
L-Type Calcium Channel Blocker VI, Simvastatin, Sodium Salt - Calbiochem
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About This Item
Linear Formula:
C25H39O6.Na
UNSPSC Code:
51111800
NACRES:
NA.32
Product Name
Simvastatin, Sodium Salt - Calbiochem,
form
(Beige solid)
Quality Level
storage condition
OK to freeze
solubility
soluble (DMSO (100 mg/ml), Ethanol (25 mg/ml), or H2O (5 mg/ml))
storage temp.
−20°C
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General description
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
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