Smac-N7 Peptide, Cell-Permeable

Name: Smac-<i>N7</i> Peptide, Cell-Permeable
Brand: MM

The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

Synonym(s):

Smac-N7 Peptide, Cell-Permeable, AVPIAQKPRQIKIWFQNRRMKWKK

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About This Item

Empirical Formula (Hill Notation):

C₁₄₂H₂₃₂N₄₄O₂₉S

Molecular Weight:

3051.70

NACRES:

NA.77

UNSPSC Code:

12352200

Product Name

Smac-N7 Peptide, Cell-Permeable, The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Promotes procaspase-3 activation

Product does not compete with ATP.

Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

The Smac-N7 peptide (Cat. No. 567370) is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

The Smac-N7 peptide (Cat. No. 567370) where the lysine carboxy terminal is linked to the arginine of Antennapedia homeodomain 16-mer peptide (underlined) via a proline linker to make it cell-permeable. Smac-N7 peptide contains the N-terminal seven residues of Smac and promotes the activation of procaspase-3 (~10 µM). Also, promotes the catalytic activity of caspase-9 in the presence of XIAP.

Other Notes

H-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH

Srinivasula, S.M., et al. 2001. Nature410, 112.
Chai, J., et al. 2000. Nature406, 855.
Liu, Z., et al. 2000. Nature408, 1004.
Srinivasula, S.M., et al. 2000. J. Biol. Chem.275, 36152.

Packaging

Packaged under inert gas

Physical form

Supplied as a trifluoroacetate salt.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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