Src Kinase Inhibitor I - CAS 179248-59-0 - Calbiochem

A 4′-phenoxy substituted 4-anilinoquinazoline compound that acts as a potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src family tyrosine kinases (IC₅₀ = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC₅₀ = 0.32 µM and 30 µM, respectively).

A potent, selective, dual site, cell-permeable, reversible and ATP-competitive inhibitor of Src tyrosine kinase (IC₅₀ = 44 nM and 88 nM for Src and Lck, respectively). Shown to simultaneously interact with both the ATP- and peptide-binding sites. Inhibits VEGFR2 and c-fms tyrosine kinases only at higher concentrations (IC₅₀ = 320 nM and 30 µM, respectively).

Cell permeable: yes

Primary Target
Src

Product competes with ATP.

Reversible: yes

Target IC₅₀: 44 nM and 88 nM for Src and Lck, respectively

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Tian, G., et al. 2001. Biochemistry40, 7084.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)