567806
Src Kinase Inhibitor II
The Src Kinase Inhibitor II, also referenced under CAS 459848-35-2, controls the biological activity of Src Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Src Kinase Inhibitor II
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About This Item
Empirical Formula (Hill Notation):
C22H20N4O3S
CAS Number:
Molecular Weight:
420.48
UNSPSC Code:
12352200
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale orange
solubility
DMSO: 20 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A potent, selective, reversible, and ATP-competitive inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR tyrosine kinase even at concentrations as high as 50 µM.
A substituted triazoloquinoline-1-thione compound that acts as a potent, ATP-competitive, reversible and selective inhibitor of Src family tyrosine kinases (IC50 = 1.2 µM for human recombinant Csk). Exhibits little effect against p38 MAPK or FGFR even at concentrations as high as 50 µM.
Biochem/physiol Actions
Cell permeable: no
Primary Target
human recombinant Csk
human recombinant Csk
Product competes with ATP.
Reversible: yes
Target IC50: 1.2 µM for human recombinant Csk
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Kilimnik, A., et al. 2003. Cell. Mol. Biol. Lett.8, 588.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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