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Key Documents

569406

Sigma-Aldrich

MF-438

≥99% (HPLC), Stearoyl-CoA Desaturase 1 (SCD1) inhibitor, powder

Synonym(s):

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, 2-methyl-5-(6-(4-(2-(trifluoromethyl)phenoxy)piperidin-1-yl)pyridazin-3-yl)-1,3,4-thiadiazole

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About This Item

Empirical Formula (Hill Notation):
C19H18F3N5OS
Molecular Weight:
421.44
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, Stearoyl-CoA Desaturase 1 Inhibitor, MF-438, CAS 921605-87-0, is a cell-permeable inhibitor of Stearoyl-CoA Desaturase 1 (SCD1; IC50 of 2.3 nM).

Quality Level

100

Assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

off-white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

Related Categories

General description

A cell-permeable, thiadiazole-pyridazine compound that acts as an inhibitor of Stearoyl-CoA Desaturase 1 (SCD1) with an IC50 of 2.3 nM. In vivo, it exhibits an ED50 of 1-3 mg/kg, p.o., in mouse liver PD assays.

Other Notes

Leger, S., et al. 2010. Bioorg Med Chem Lett.2, 499.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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