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Merck

573121

SMER28

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.

Synonym(s):

SMER28, (6-Bromo-4-allylamino)quinazoline, Small- Molecule Enhancer of Rapamycin-28, Autophagy Inducer II, (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II

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About This Item

Empirical Formula (Hill Notation):
C11H10BrN3
CAS Number:
307538-42-7
Molecular Weight:
264.12
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD02166825

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Product Name

SMER28, A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.

SMILES string

Brc1cc2c(ncnc2NCC=C)cc1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

InChI key

BCPOLXUSCUFDGE-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

ethanol: 10 mg/mL
DMSO: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Other Notes

Tian, Y., et al. 2011. FASEB J.25, 1934.Sarkar, S., et al. 2007. Nat. Chem. Biol.3, 331.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

General description

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Certificates of Analysis (COA)

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