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574715

Syk Inhibitor V

Name: Syk Inhibitor V
Brand: MM

The Syk Inhibitor V controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Syk Inhibitor V, (S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₂₃N₅O₂S

CAS Number:

1096156-20-5

Molecular Weight:

397.49

UNSPSC Code:

12352200

Quality Level

100

Assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 50 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

SMILES string

CC1=CC(C)=CC(NC2=NC=CC(C3=NC(C)=C(C(N[C@@H](C)CO)=O)S3)=N2)=C1

General description

A cell-permeable 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (K_i = 9nM). Exhibits excellent selectivity over Cdk2 (K_i ≥ 3.33 µM); ROCK K_i = 2.3 µM), Src K_i ≥ 3.33 µM) and ZAP 70 (K_i = 240 nM). Shown to inhibit mast cell degranulation (IC₅₀ = 70 nM) that is commonly observed in asthma and other allergic diseases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°c.

Other Notes

Farmer, L., et al. 2008. Bioorg. Med. Chem. Lett.18, 6231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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