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Merck

574715

Syk Inhibitor V

The Syk Inhibitor V controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Syk Inhibitor V, (S)-2-(2-((3,5-dimethylphenyl)amino)pyrimidin-4-yl)-N-(1-hydroxypropan-2-yl)-4-methylthiazole-5-carboxamide, Spleen Tyrosine Kinase Inhibitor

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About This Item

Empirical Formula (Hill Notation):
C20H23N5O2S
CAS Number:
1096156-20-5
Molecular Weight:
397.49
UNSPSC Code:
12352200
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

CC1=CC(C)=CC(NC2=NC=CC(C3=NC(C)=C(C(N[C@@H](C)CO)=O)S3)=N2)=C1

assay

≥99% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL, pale yellow

shipped in

ambient

storage temp.

−20°C

Quality Level

100

General description

A cell-permeable 4-thiazolyl-2-phenylaminopyrimidine compound that acts as a potent, reversible and ATP-competitive inhibitor of spleen tyrosine kinase (Syk) (Ki = 9nM). Exhibits excellent selectivity over Cdk2 (Ki ≥ 3.33 µM); ROCK Ki = 2.3 µM), Src Ki ≥ 3.33 µM) and ZAP 70 (Ki = 240 nM). Shown to inhibit mast cell degranulation (IC50 = 70 nM) that is commonly observed in asthma and other allergic diseases.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°c.

Other Notes

Farmer, L., et al. 2008. Bioorg. Med. Chem. Lett.18, 6231.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Regulatory Review (Z)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Priyanka Ramesh et al.
Pharmaceutics, 13(11) (2021-11-28)
Rearranged during transfection (RET) is a tyrosine kinase oncogenic receptor, activated in several cancers including non-small-cell lung cancer (NSCLC). Multiple kinase inhibitors vandetanib and cabozantinib are commonly used in the treatment of RET-positive NSCLC. However, specificity, toxicity, and reduced efficacy

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