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Merck

575307

T113242

A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin.

Synonym(s):

T113242, T1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide

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About This Item

Empirical Formula (Hill Notation):
C14H11F5N2O2S
CAS Number:
195533-44-9
Molecular Weight:
366.31
MDL number:
MFCD09039063
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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Quality Level

100

InChI key

CLMSOSHEPLACPG-UHFFFAOYSA-N

InChI

1S/C14H11F5N2O2S/c1-21(2)8-5-3-7(4-6-8)20-24(22,23)14-12(18)10(16)9(15)11(17)13(14)19/h3-6,20H,1-2H3

SMILES string

Fc1c(c(c(c(c1F)F)[S](=O)(=O)Nc2ccc(cc2)N(C)C)F)F

assay

≥90% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 200 mg/mL, methanol: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

General description

A cell-permeable pentafluorosulfonamide compound that covalently binds to β-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).

Biochem/physiol Actions

Cell permeable: yes
Primary Target
β-tubulin
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 458.
Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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