575307
T113242
A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin.
Synonym(s):
T113242, T1, (4-N,Nʹ-Dimethylanilino)-pentafluorosulfonamide
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About This Item
Empirical Formula (Hill Notation):
C14H11F5N2O2S
CAS Number:
Molecular Weight:
366.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥90% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥90% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 200 mg/mL, methanol: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
Fc1c(c(c(c(c1F)F)[S](=O)(=O)Nc2ccc(cc2)N(C)C)F)F
InChI
1S/C14H11F5N2O2S/c1-21(2)8-5-3-7(4-6-8)20-24(22,23)14-12(18)10(16)9(15)11(17)13(14)19/h3-6,20H,1-2H3
InChI key
CLMSOSHEPLACPG-UHFFFAOYSA-N
General description
A cell-permeable pentafluorosulfonamide compound that covalently binds to β-tubulin and induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcription has been shown to be mediated by the Erk signaling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
β-tubulin
β-tubulin
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Ziegelbauer, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 458.
Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.
Ziegelbauer, J., et al. 2001. Mol. Cell8, 339.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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