Tautomycin, Streptomyces spiroverticillatus

Mixture of two isomers. Potent inhibitor of protein phosphatases and useful for studies involving protein phosphorylation. Inhibits protein phosphatase 1 (IC₅₀ = 1 nM), protein phosphatase 2A (IC₅₀ = 10 nM), and smooth muscle endogenous phosphatase (IC₅₀ = 6 nM). Higher concentrations are needed to inhibit protein phosphatase 2B. Does not inhibit protein phosphatase 2C or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase.

Cell permeable: no

Primary Target
PP1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 1 nM, 10 nM, 6 nM, against protein phosphatase 1, protein phosphatase 2A, and smooth muscle endogenous phosphatase, respectively

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.







From Catalog:

Desc. Field- removed ". . .and useful for studies involving protein phosphorylation"

- removed ". . .or phorbol dibutyrate binding. Does not activate protein kinase C or inhibit myosin light chain kinase"

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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Highly Toxic (H)