581011
Telomerase Inhibitor IX
The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
Telomerase Inhibitor IX, MST-312, N,Nʹ-bis(2,3-Dihydroxybenzoyl)-1,3-phenylenediamine
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About This Item
Empirical Formula (Hill Notation):
C20H16N2O6
CAS Number:
Molecular Weight:
380.35
UNSPSC Code:
12352200
NACRES:
NA.54
MDL number:
Assay:
≥95% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 5 mg/mL
shipped in
wet ice
storage temp.
−20°C
SMILES string
N(c2cc(ccc2)NC(=O)c3c(c(ccc3)O)O)C(=O)c1c(c(ccc1)O)O
InChI
1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
InChI key
MIQUEZGHEJGPJB-UHFFFAOYSA-N
General description
A cell-permeable, bis-catechol containing, m-phenylenediamide compound that displays anti-proliferative properties. Acts as a potent, reversible inhibitor of telomerase activity (IC50 = 670 nM, TRAP lysate prepared from U937 cells). Prolonged treatment with MST-312 has been reported to result in telomere shortening and growth arrest in U937 cells. Does not inhibit the activity of Taq DNA polymerase (IC50 >3 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
TRAP lysate prepared from U937 cells
TRAP lysate prepared from U937 cells
Product does not compete with ATP.
Reversible: yes
Target IC50: 670 nM against telomerase activity in TRAP lysate prepared from U937 cells
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Seimiya, H., et al. 2005. Cancer Cell7, 25.
Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.
Seimiya, H., et al. 2002. Mol. Cancer Ther.1, 657.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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