603425
Threonine Dehydrogenase Inhibitor, QC1
The Threonine Dehydrogenase Inhibitor, QC1 controls the biological activity of Threonine Dehydrogenase.
Synonym(s):
Threonine Dehydrogenase Inhibitor, QC1, N-Benzyl-4-oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C23H16F3N3O2S
CAS Number:
Molecular Weight:
455.45
UNSPSC Code:
12352200
MDL number:
Assay:
≥96% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥96% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable quinazolinecarboxamide (QC) compound that acts as a potent, reversible and mixed noncompetitive inhibitor of threonine dehydrogenase activity (IC50 ~ 0.5 µM for mTDH) with excellent selectivity over hydroxysteroid, alcohol, lactate, or glucose-6-phosphate dehydrogenases (IC50 >10 µM). Shown to block threonine catabolism, induce autophagy and impede the growth of highly proliferating mouse embryonic stem cells (mESCs; EC50 ~3 µM) with no effect on ESCs-derived embryoid body cells, 3T3 fibroblasts or tumor cells (EC50 ~1 mM).
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Alexander, P.B., et al. 2011. Proc. Natl. Acad. Sci. USA108, 15828.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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