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Merck

605160

Thrombin, Plasminogen-Free, Bovine

Synonym(s):

Thrombin, Plasminogen-Free, Bovine

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About This Item

CAS Number:
9002-04-4
MDL number:
MFCD00236878
NACRES:
NA.25
UNSPSC Code:
12352204

description

Merck USA index - 14, 9383

form

lyophilized

specific activity

≥1000 NIH units/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated

solubility

water: 1 mg/mL

foreign activity

Plasminogen, none detected (by rocket IEP)

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Analysis Note

Complete activation from homogeneous bovine prothrombin by SDS-PAGE

Disclaimer

Toxicity: Harmful (C)

General description

Native, bovine thrombin. Key enzyme that activates factor XIII and converts fibronogen into fibrin. Serine protease formed in the plasma during the coagulation process by activation of prothrombin by a complex of Factor Xa, Factor Va, phospholipid, and Ca2+. Thrombin cleaves Arg-Gly bonds in specific sequences only. The best characterized activity of thrombin is the conversion of fibrinogen to fibrin in the clotting process. Inhibited by AEBSF (Cat. No. 101500) Antithrombin (Cat. No. 169756), PMSF (Cat. No. 52332), and TLCK (Cat. No. 616382). Note: 1 KU = 1000 units.

Other Notes

One unit is determined by comparison with a standard curve prepared using the Bureau of Biologics standard thrombin.

Physical form

Lyophilized from 200 mM NaCl, 50 mM sodium citrate, 0.1% PEG-8000, pH 6.5.

Preparation Note

Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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