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Merck

605197

Thrombin-Activatable Fibrinolysis Inhibitor, Human

The Thrombin-Activatable Fibrinolysis Inhibitor, Human controls the biological activity of Thrombin-Activatable Fibrinolysis. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

Plasma Procarboxypeptidase B, TAFI

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About This Item

NACRES:
NA.25
UNSPSC Code:
12352202

Product Name

Thrombin-Activatable Fibrinolysis Inhibitor, Human, The Thrombin-Activatable Fibrinolysis Inhibitor, Human controls the biological activity of Thrombin-Activatable Fibrinolysis. This small molecule/inhibitor is primarily used for Biochemicals applications.

assay

≥95% (SDS-PAGE)

form

liquid

specific activity

2-9 units/mg protein

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

shipped in

wet ice

storage temp.

−70°C

Quality Level

100

Preparation Note

Following initial thaw, aliquot and freeze (-70°C).
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Other Notes

Boffa, M.B., et al. 1999. Biochemistry 38, 6547.
Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.
One unit is defined as the amount of enzyme that will hydrolyze 1 µM Hip-L-Arg per min at 25°C, pH 7.65.

Disclaimer

Toxicity: Standard Handling (A)

General description

Native thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. ctivated by the thrombin/thrombomodulin complex by proteolytic cleavage at Arg92. Circulates in plasma as a zymogen at a concentration of about 50 nM. Believed to play an important role in the interaction between procoagulant, anticoagulant, and fibrinolytic systems.

Packaging

Please refer to vial label for lot-specific concentration.

Physical form

In 150 mM NaCl, 20 mM HEPES, pH 7.4.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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