605225
Thrombospondin, Human Platelets
Synonym(s):
Thrombospondin protein
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352202
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
description
Merck USA index - 14 9387
Quality Segment
assay
≥95% (SDS-PAGE)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
water: soluble
shipped in
wet ice
storage temp.
−70°C
General description
Native thrombospondin purified from human platelets. Adhesive glycoprotein released in response to platelet activation by α-thrombin. An angiogenesis inhibitor that blocks the FGF-induced neovascularization of the rat cornea. An inducer of platelet aggregation. Synthesized by a number of different cells and secreted into the extracellular matrix. Involved in the regulation of cellular proliferation.
Physical form
Lyophilized from 600 mM NaCl, 20 mM Tris, 1 mM CaCl₂, 20% sucrose, pH 7.8.
Preparation Note
Following reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for 1 week at 4°C or for at least 1 month at -70°C. Product is extremely adherent to surfaces; keep frozen (-70°C) before use and use siliconized surfaces to insure product recovery.
Please refer to lot-specific reconstitution volume on the vial label.
Prepared from platelets that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
Armstrong, L.C., et al. 2002. Mol. Biol. Cell13, 1893.
Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
Koch, A.E., et al. 1993. Pathobiology 61, 1.
Tolsma, S.S., et al. 1993. J. Cell Biol.122, 497.
Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA87, 6624.
Michaund, M. and Poyet, O. 1994. Anticancer Res. 14, 1127.
Castle, V.P., et al. 1993. J. Biol. Chem. 268, 2899.
Koch, A.E., et al. 1993. Pathobiology 61, 1.
Tolsma, S.S., et al. 1993. J. Cell Biol.122, 497.
Tuszynski, G.P., et al. 1993. J. Cell Biol. 120, 513.
Schon, P., et al. 1992. Eur. J. Cell Biol. 59, 329.
Good, D.J., et al. 1990. Proc. Natl. Acad. Sci. USA87, 6624.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
This product is regulated in France when intended for scientific purposes, including import, export, and conservation activities (Articles L.1211-1, paragraph 2, and L.1243-4 of the French Public Health Code). The purchaser (i.e. end user) is required to obtain an import authorization from the France Ministry responsible for Research (as referenced in Article L.1245-5-1 II of the French Public Health Code) or a conservation authorization from the same ministry (as referenced in Article L.1243-4 of the French Public Health Code). By placing an order for this product, you confirm that you have obtained the appropriate import or conservation authorization for the product. For more information regarding the use of human biological samples for research purposes in France, please contact the relevant French authorities.
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
WGK
WGK 1
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