612084
TIMP-2, Human Rheumatoid Synovial Fibroblast
Native TIMP-2 from human rheumatoid synovial fibroblast.
Synonym(s):
Tissue Inhibitor of Metalloproteinase-2
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About This Item
UNSPSC Code:
12352202
Assay:
≥90% (SDS-PAGE)
Form:
liquid
Quality level:
Storage condition:
OK to freeze
avoid repeated freeze/thaw cycles
avoid repeated freeze/thaw cycles
Product Name
TIMP-2, Human Rheumatoid Synovial Fibroblast, Native TIMP-2 from human rheumatoid synovial fibroblast.
assay
≥90% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-1
MMP-1
Product does not compete with ATP.
Reversible: no
Disclaimer
Toxicity: Standard Handling (A)
General description
Native TIMP-2 from human rheumatoid synovial fibroblast. Member of a family of inhibitors that participate in the activation and regulation of MMP activity. Forms a non-covalent stoichiometric complex with latent and active MMPs. Shown to inhibit the activities of MMP-1, MMP-2, MMP-12, and transin.
Other Notes
Greene, J., et al. 1996. J. Biol. Chem. 271, 30375.
Miyazaki, K., et al. 1993. J. Biol. Chem. 268, 14387.
Miyazaki, K., et al. 1993. J. Biol. Chem. 268, 14387.
Physical form
In 200 mM NaCl, 50 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% Brij® 35 Detergent, pH 7.0.
Preparation Note
Prepared from fibroblasts that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Legal Information
Brij is a registered trademark of Croda International PLC
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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