616403
TACE Substrate III, Fluorogenic
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE (Km = 19 µM).
Synonym(s):
TACE Substrate III, Fluorogenic, TNF-α Convertase Enzyme Substrate II, Fluorogenic, ADAM-17 Substrate II, Fluorogenic, DABCYL-LAQAVRSSSR-EDANS, TNF-α Convertase Enzyme Substrate II, Fluorogenic, DABCYL-LAQAVRSSSR-EDANS, ADAM-17 Substrate II, Fluorogenic
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About This Item
Empirical Formula (Hill Notation):
C70H104N22O18S
CAS Number:
Molecular Weight:
1573.78
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
lyophilized solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
red
solubility
50% acetic acid: 5 mg/mL, DMSO: 5 mg/mL
fluorescence
λex ~340 nm, λem ~490 nm
shipped in
ambient
storage temp.
−20°C
General description
A fluorescence energy transfer (FRET) peptide substrate for tumor necrosis factor (TNF)-α convertase (TACE) (Km ~19 µM). Cleavage occurs between the alanine and valine residues. Useful for screening TACE inhibitors. Excitation max: ~340 nm; emission max: ~490 nm.
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE (Km = 19 µM). Substrate cleavage occurs at the Ala-Val bond. Useful for the screening of TACE and SARS protease 3-CLPRO inhibitors.
Biochem/physiol Actions
Cell permeable: no
Km = 19 µM as a fluorescence resonance energy transfer (FRET) peptide substrate for TACE
Primary Target
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE
A fluorescence resonance energy transfer (FRET) peptide substrate for TACE
Product does not compete with ATP.
Reversible: no
Packaging
Yes
Physical form
Supplied as a trifluoroacetate salt.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Bacha, U., et al. 2004. Biochemistry43, 4906.
Patel, I.R., et al. 1998. J. Immunol.160, 4570.
Patel, I.R., et al. 1998. J. Immunol.160, 4570.
DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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