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658408

AG 490, m-CF₃

Name: AG 490, <i>m</i>-CF<SUB>3</SUB>
Brand: MM

A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 that displays apoptotic and antiproliferative properties.

Synonym(s):

AG 490, m-CF₃, NSC D722757, α-Cyano-(3,4-dihydroxy)-N-( m-trifluoromethyl)benzylcinnamide, 5H4, NSC D722757, α-Cyano-(3,4-dihydroxy)-N-(m-trifluoromethyl)benzylcinnamide, 5H4

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₃F₃N₂O₃

CAS Number:

581797-29-7

Molecular Weight:

362.30

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 0.5 mg/mL, methanol: soluble

shipped in

ambient

storage temp.

−20°C

InChI

1S/C18H13F3N2O3/c19-18(20,21)14-3-1-2-12(7-14)10-23-17(26)13(9-22)6-11-4-5-15(24)16(25)8-11/h1-8,24-25H,10H2,(H,23,26)

InChI key

CBZPIGMULPRVPO-UHFFFAOYSA-N

Description

General description

A cell-permeable, reversible, substrate competitive, m-trifluoromethyl derivative of AG 490 (Cat. No. 658401) that displays apoptotic and antiproliferative properties (IC₅₀ = 1.7 µM, 2.8 µM and 6.1 µM in 2E8, Baf/3 and Jurkat cells, respectively). Shown to inhibit IL-7-induced JAK3 tyrosine phosphorylation in 2E8 cells in vitro and significantly reduce lymph node cellularity in a murine B and T cell lymphoma model (1 mg per animal, i.p.) in vivo.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
apoptotic and antiproliferative properties

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 1.7 µM, 2.8 µM and 6.1 µM for displaying apoptotic and antiproliferative properties in 2E8, Baf/3 and Jurkat cells, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 weeks at -20°C.

Other Notes

Gu, L., et al. 2005. Bioorg. Med. Chem.13, 4269.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c