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U 18666A

Name: U 18666A
Brand: MM

≥95% (HPLC), lyophilized solid, δ8-sterol isomerase inhibitor, Calbiochem^®

Synonym(s):

U18666A, 3β-(2-Diethylaminoethoxy)androst-5-en-17-one, HCl

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₄₁NO₂ · xHCl

CAS Number:

3039-71-2

Molecular Weight:

387.60 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00210908

Assay:

≥95% (HPLC)

Form:

lyophilized solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Properties

Product Name

U18666A, A cell-permeable, amphiphilic amino-steroid that alters intracellular membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol.

Quality Segment

100

assay

≥95% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Cl-].N(CCOC1CC2(C3C(C4C(CC3)(C(=O)CC4)C)CC=C2CC1)C)(CC)CC.[H+]

InChI

1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-9-7-18-8-10-20-21-11-12-23(27)24(21,3)14-13-22(20)25(18,4)17-19;/h8,19-22H,5-7,9-17H2,1-4H3;1H

InChI key

ICPRVJHNLABCSA-UHFFFAOYSA-N

Description

General description

A cell-permeable, amphiphilic amino-steroid that alters intracelluar membrane protein trafficking by impairing intracellular biosynthesis and transport of LDL-derived cholesterol. Reported to exert its effects via the inhibition of 2,3-oxidosqualene-lanosterol cyclase activity. Also reported to inhibit the activity of Δ⁸-sterol isomerase.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Activity of δ8-sterol isomerase

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hall, A.M., et al. 2003. Pigment Cell Res.16, 149.
Kobayashi, T., et al. 1998. Nature392, 193.
Liscum, L. and Faust, J.R., 1989. J. Biol. Chem.264, 11796.
Sexton, R.C., et al. 1983. Biochemistry22, 5687.
Bierkamper, G.G. and Cenedella, R.J., 1978. Brain Res.150, 343.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c