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Merck

662088

UCH-L1 Inhibitor II

The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

UCH-L1 Inhibitor II, Ubiquitin C-terminal Hydrolase-L1 Inhibitor II, 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid, LDN-91946

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About This Item

CAS Number:
439946-22-2
UNSPSC Code:
12352200

Key Documents

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Product Name

UCH-L1 Inhibitor II, The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

assay

≥85% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

brown

solubility

DMSO: 50 mg/mL

storage temp.

2-8°C

Disclaimer

Toxicity: Standard Handling (A)

General description

A thienopyridinone compound that inhibits UCH-L1-catalyzed substrate hydrolysis (Ki app = 2.8 µM with Ub-AMC as the substrate) in an uncompetitive manner by targeting the enzyme-substrate complex, but not the free enzyme, while exhibiting little activity against UCH-L3, TGase 2, Papain, or Caspase-3 even at concentrations as high as 20 µM.
The UCH-L1 Inhibitor II, also referenced under CAS 439946-22-2, controls the biological activity of UCH-L1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Other Notes

Mermerian, A.H., et al. 2007. Bioorg. Med. Chem. Lett.17, 3729.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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