662098
UbcH5c Conjugating Enzyme E2, Human, Recombinant, E. coli
Synonym(s):
UBD2D3, Ubiquitin-conjugating enzyme E2 D3
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About This Item
UNSPSC Code:
12352203
assay
≥95% (SDS-PAGE)
form
solution
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−70°C
Quality Level
Disclaimer
Toxicity: Standard Handling (A)
General description
Full-length, recombinant, human UbcH5c expressed in E. coli. UbcH5c, an E2 ubiquitin ligase, is highly homologous to the yeast UbC4/5 family of E2 enzymes. UbcH5c, together with UbcH5a and UbcH5b, are the most active class of E2 enzymes in cell extracts and are associated with regulation of transcription factors such as p53, NF-κB3, and c-Fos. The active enzyme is useful in the study of ubiquitin regulation and inhibitor screening.
Other Notes
Brzovic, P.S., et al. 2006. Cell Cycle5, 2867.
Gehrke, S.G., et al. 2003 Blood.101, 3288.
Nuber, U., And Scheffner, M., 1999. J. Biol. Chem.274, 7576.
Schwarz, S.E., et al. 1998. J. Biol. Chem.273, 12148.
Jensen, J., et al. 1995. J. Biol. Chem.270, 30408.
Scheffner, M., et al. 1994. Proc. Natl. Acad. Sci.91, 8797.
Gehrke, S.G., et al. 2003 Blood.101, 3288.
Nuber, U., And Scheffner, M., 1999. J. Biol. Chem.274, 7576.
Schwarz, S.E., et al. 1998. J. Biol. Chem.273, 12148.
Jensen, J., et al. 1995. J. Biol. Chem.270, 30408.
Scheffner, M., et al. 1994. Proc. Natl. Acad. Sci.91, 8797.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In 50 mM HEPES, 50 mM NaCl, 1 mM DTT, 10% glycerol, pH 7.0.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
Certificates of Analysis (COA)
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