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Merck

681500

WHI-P180

A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo.

Synonym(s):

WHI-P180, 4-(3ʹ-Hydroxyphenyl)amino-6,7-dimethoxyquinazoline

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About This Item

Empirical Formula (Hill Notation):
C16H15N3O3
CAS Number:
211555-08-7
Molecular Weight:
297.31
MDL number:
MFCD02683970
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, protect from light

Key Documents

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SMILES string

N(c3cc(ccc3)O)c1ncnc2c1cc(c(c2)OC)OC

InChI

1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)

InChI key

BNDYIYYKEIXHNK-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

General description

A potent inhibitor of IgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.
A potent inhibitor of lgE-mediated mast cell responses to allergens in vitro and in vivo. Also inhibits cyclin-dependent kinase 2 (Cdk2; IC50 = 1 µM) by blocking the ATP site.

Biochem/physiol Actions

Product does not compete with ATP.
Reversible: no
Target IC50: 1 µM for Cdk2
Cell permeable: no
Primary Target
Cdk2

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Shewchuk, L., et al. 2000. J. Med. Chem. 43, 133.
Chen, C.L., et al. 1999. Pharm. Res. 16, 117.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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