681625
W-5, Hydrochloride
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
Synonym(s):
W-5, Hydrochloride, N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
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About This Item
Empirical Formula (Hill Notation):
C16H22N2O2S · xHCl
CAS Number:
Molecular Weight:
306.42 (free base basis)
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (NMR)
Form:
crystalline solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Segment
assay
≥98% (NMR)
form
crystalline solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
solubility
DMSO: soluble, water: soluble
shipped in
ambient
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(NCCCCCCN)c1c2c(ccc1)cccc2.[Cl-].[H+]
InChI
1S/C16H22N2O2S.ClH/c17-12-5-1-2-6-13-18-21(19,20)16-11-7-9-14-8-3-4-10-15(14)16;/h3-4,7-11,18H,1-2,5-6,12-13,17H2;1H
InChI key
HOCSVIGHWPLMFC-UHFFFAOYSA-N
General description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
Biochem/physiol Actions
Cell permeable: yes
Product does not compete with ATP.
Reversible: yes
Target IC50: 230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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