Skip to Content
Merck

681640

Wee1 Inhibitor

≥97% (HPLC), solid

Synonym(s):

Wee1 Inhibitor, 4-(2-Chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione, Chk1 Inhibitor V

Sign In to View Organizational & Contract Pricing.

Select a Size

All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C20H11ClN2O3
CAS Number:
622855-37-2
Molecular Weight:
362.77
MDL number:
MFCD28138102
UNSPSC Code:
12352200
NACRES:
NA.77

Product Name

Wee1 Inhibitor, The Wee1 Inhibitor, also referenced under CAS 622855-37-2, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

SMILES string

Clc1c(cccc1)c2c3c(c4c([nH]c5c4cc(cc5)O)c2)[c]([nH][c]3=O)=O

InChI

1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26)

InChI key

DPEXRCOBPACFOO-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

solid

potency

11 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

light orange

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
Product competes with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 440 nM).

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service