Key Documents

View All Documentation

681641

Wee1 Inhibitor II

Name: Wee1 Inhibitor II
Brand: MM

The Wee1 Inhibitor II, also referenced under CAS 622855-50-9, controls the biological activity of Wee1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Wee1 Inhibitor II, 6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₄H₁₉ClN₂O₃

CAS Number:

622855-50-9

Molecular Weight:

418.87

MDL number:

MFCD28138108

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

brown

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Clc1c(cccc1)c2c3c(c4c([n](c5c4cc(cc5)O)CCCC)c2)[c]([nH][c]3=O)=O

InChI

1S/C24H19ClN2O3/c1-2-3-10-27-18-9-8-13(28)11-16(18)20-19(27)12-15(14-6-4-5-7-17(14)25)21-22(20)24(30)26-23(21)29/h4-9,11-12,28H,2-3,10H2,1H3,(H,26,29,30)

InChI key

HLSZACLAFZWCCS-UHFFFAOYSA-N

Description

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 35 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Wee1

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 59 nM against Wee1

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c