682162
Xestospongin D, Xestospongia sp.
A reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM).
Synonym(s):
Xestospongin D, Xestospongia sp., XeD
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About This Item
Empirical Formula (Hill Notation):
C28H50N2O3
Molecular Weight:
462.71
UNSPSC Code:
12352200
assay
≥90% (TLC)
form
film
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
clear
solubility
ethanol: 1 mg/mL, methanol: 1 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Cell permeable: no
Primary Target
IP3-mediated Ca2+
IP3-mediated Ca2+
Product does not compete with ATP.
Reversible: yes
Target IC50: 648 nM in blocking IP3-mediated Ca2+ release
Disclaimer
Toxicity: Harmful (C)
General description
A membrane-permeable, reversible blocker of IP3-mediated Ca2+ release (IC50 = 648 nM) that is less potent than XeC (Cat. No. 682160). Also displays a high selectivity over the skeletal isoform of the ryanodine receptor type 1 (Ry1R).
A reversible, membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 648 nM). Also displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1).
Other Notes
Gafni, J., et al. 1997. Neuron 19, 723.
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227
Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
Nakagawa, M., et al. 1984. Tetrahedron Lett.25, 3227
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sonication may be required to achieve complete solubilization.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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