8.18043
Trifluoromethanesulfonic anhydride
for synthesis
Synonym(s):
Trifluoromethanesulfonic anhydride
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About This Item
Quality Level
assay
≥99.0% (acidimetric)
form
liquid
potency
1012 mg/kg LD50, oral (Rat)
density
1.71 g/cm3 at 20 °C
storage temp.
2-30°C
SMILES string
FC(F)(F)[S](=O)(=O)O[S](=O)(=O)C(F)(F)F
InChI
1S/C2F6O5S2/c3-1(4,5)14(9,10)13-15(11,12)2(6,7)8
InChI key
WJKHJLXJJJATHN-UHFFFAOYSA-N
Application
- Electrophilic activation using trifluoromethanesulfonic anhydride: This method is utilized for transformations of amides, sulfoxides, and phosphorus oxides through nucleophilic trapping, highlighting its versatility in organic synthesis (Huang and Kang, 2022).
- Triflic anhydride in organic synthesis: A comprehensive review of triflic anhydride′s roles, focusing on its application across various organic transformations (Qin, Cheng, and Jiao, 2023).
- Synthesis of nitriles: Employing trifluoromethanesulfonic anhydride for converting aldoximes to nitriles under mild conditions, showcasing an innovative application in nitrile synthesis (Uludag, 2020).
- Hydrotrifluoromethylthiolation of alkenes: Uses trifluoromethanesulfonic anhydride for the hydrotrifluoromethylthiolation of unactivated alkenes and alkynes, expanding the utility of this reagent in radical reactions (Ouyang, Xu, and Qing, 2019).
- Low-cost trifluoromethylation reagent: Discusses the economic benefits and wide-ranging applications of trifluoromethanesulfonic anhydride in trifluoromethylation processes (Ouyang, Xu, and Qing, 2018).
Analysis Note
Density (d 20 °C/ 4 °C): 1.715 - 1.720
Identity (IR): passes test
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Danger
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Ox. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Respiratory system
Storage Class
5.1B - Oxidizing hazardous materials
wgk
WGK 3
hcodes
flash_point_f
not determinedboils before flash
flash_point_c
not determinedboils before flash
Certificates of Analysis (COA)
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