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8.20560

Sigma-Aldrich

Isopropyl acetate

greener alternative

for synthesis

Synonym(s):

Isopropyl acetate

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About This Item

Linear Formula:
CH3COOCH(CH3)2
CAS Number:
108-21-4
Molecular Weight:
102.13
MDL number:
MFCD00008877
UNSPSC Code:
12352108
EC Index Number:
203-561-1
NACRES:
NA.22

vapor pressure

61 hPa ( 20 °C)

Quality Level

200

Assay

≥99% (GC)

form

liquid

autoignition temp.

460 °C

potency

6750 mg/kg LD50, oral (Rat)
>20000 mg/kg LD50, skin (Rabbit)

expl. lim.

1.8-8 % (v/v)

greener alternative product characteristics

Safer Solvents and Auxiliaries
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sustainability

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bp

88-90 °C/1013 hPa

mp

-73 °C

transition temp

flash point 4 °C

density

0.87 g/cm3 at 20 °C

greener alternative category

Aligned

storage temp.

2-30°C

SMILES string

O(C(C)C)C(=O)C

InChI

1S/C5H10O2/c1-4(2)7-5(3)6/h4H,1-3H3

InChI key

JMMWKPVZQRWMSS-UHFFFAOYSA-N

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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. This product is aligned with "Safer Solvents and Auxiliaries". Click here for more information.

Application

Isopropyl acetate can be used as an:
  • Acyl donor in stereoselective biotransformations of chiral amines.
  • Alkylating agent for the isopropylation of phenols due to its easy chemisorption on the Bronsted acid sites to form alkyl cations and the release of acetic acid in the reaction that can stabilize the charged structure of phenol.

Analysis Note

Assay (GC, area%): ≥ 99 %
Density (d 20 °C/ 4 °C): 0.871 - 0.873
Identity (IR): passes test

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Statements

H225 - H319 - H336

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

41.0 °F

Flash Point(C)

5 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Isopropyl 2-ethoxyacetate-an efficient acylating agent for lipase-catalyzed kinetic resolution of amines in batch and continuous-flow modes
Olah M, et al.
Tetrahedron, 72, 7249-7255 (2016)
Catalytic performance of Al-MCM-48 molecular sieves for isopropylation of phenol with isopropyl acetate
Venkatachalam K, et al.
Chinese Journal of Catalysis, 33, 478-486 (2012)

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