8.51056
HOSu
Novabiochem®
Synonym(s):
HOSu, 1-Hydroxy-2,5-pyrrolidinedione, N-Hydroxysuccinimide, NHS
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About This Item
Empirical Formula (Hill Notation):
C4H5NO3
CAS Number:
Molecular Weight:
115.09
UNSPSC Code:
12352005
EC Index Number:
228-001-3
NACRES:
NA.22
MDL number:
Quality Level
product line
Novabiochem®
assay
≥99.0% (acidimetric)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
pH
5-7 (20 °C, 50 g/L in H2O)
mp
93-100 °C
application(s)
peptide synthesis
storage temp.
2-8°C
SMILES string
N1(C(=O)CCC1=O)O
InChI
1S/C4H5NO3/c6-3-1-2-4(7)5(3)8/h8H,1-2H2
InChI key
NQTADLQHYWFPDB-UHFFFAOYSA-N
General description
Reagent used for the synthesis of water-soluble active esters and as an additive to suppress enantiomerization during carbodiimide condensations [1,2].
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] G. W. Anderson, et al. (1964) J. Am. Chem. Soc., 86, 1839.
[2] F. Weygand, et al. (1966) Z. Naturforsch., 21, 426.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] G. W. Anderson, et al. (1964) J. Am. Chem. Soc., 86, 1839.
[2] F. Weygand, et al. (1966) Z. Naturforsch., 21, 426.
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Solubility (1 mmole in 2 ml DMF): clearly soluble
Identity (IR): passes test
Appearance of substance (visual): powder
Assay (acidimetric): ≥ 99.0 %
Melting range (lower value): ≥ 95 °C
Melting range (upper value): ≤ 100 °C
Solubility (1 mmole in 2 ml DMF): clearly soluble
Identity (IR): passes test
Other Notes
Replaces: 01-62-0009
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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