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8.52036

Fmoc-Hyp(tBu)-OH

Name: Fmoc-Hyp(tBu)-OH
Brand: MM

≥98.0% (HPLC), for peptide synthesis, Novabiochem^®

Synonym(s):

Fmoc-Hyp(tBu)-OH, N-α-Fmoc-O-t.-butyl-L-trans-4-hydroxyproline

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₂₇NO₅

CAS Number:

122996-47-8

Molecular Weight:

409.47

UNSPSC Code:

12352209

NACRES:

NA.22

MDL number:

MFCD00151930

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Properties

Product Name

Fmoc-Hyp(tBu)-OH, Novabiochem^®

Quality Segment

200

product line

Novabiochem^®

assay

≥95.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

mp

63 °C

application(s)

peptide synthesis

functional group

hydroxyl

storage temp.

15-25°C

SMILES string

N4([C@@H](C[C@H](C4)OC(C)(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C24H27NO5/c1-24(2,3)30-15-12-21(22(26)27)25(13-15)23(28)29-14-20-18-10-6-4-8-16(18)17-9-5-7-11-19(17)20/h4-11,15,20-21H,12-14H2,1-3H3,(H,26,27)/t15-,21+/m1/s1

InChI key

WPBXBYOKQUEIDW-VFNWGFHPSA-N

Description

General description

Standard building block for introduction of hydroxyproline amino-acid residues by Fmoc SPPS

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Application

Rational design of plant hairpin-like peptide EcAMP1: Structural–functional correlations to reveal antibacterial and antifungal activity: Discusses the use of Fmoc-Hyp(tBu)-OH in designing peptides that exhibit significant antibacterial and antifungal properties (Barashkova et al., 2022).

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 95.0 %
Water (K. F.): ≤ 1.50 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1078

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c