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Merck

8.52040

Fmoc-Lys(Tfa)-OH

Novabiochem®

Synonym(s):

Fmoc-Lys(Tfa)-OH, N-α-Fmoc-N-ε-trifluoroacetyl-L-lysine

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About This Item

Empirical Formula (Hill Notation):
C23H23F3N2O5
CAS Number:
Molecular Weight:
464.43
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
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Quality Level

product line

Novabiochem®

assay

≥97% (TLC), ≥97.0% (HPLC), ≥97.0% (acidimetric)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

150-160 °C

application(s)

peptide synthesis

functional group

amine

storage temp.

2-30°C

SMILES string

FC(F)(F)C(=O)NCCCC[C@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)C(=O)O

InChI

1S/C23H23F3N2O5/c24-23(25,26)21(31)27-12-6-5-11-19(20(29)30)28-22(32)33-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18-19H,5-6,11-13H2,(H,27,31)(H,28,32)(H,29,30)/t19-/m0/s1

InChI key

ZVLMWTPNDXNXSZ-IBGZPJMESA-N

General description

Building block for introduction of lysine amino-acid residues bearing orthogonal side-chain protection. The trifluoroacetyl group can be selectively removed by aqueous basic hydrolysis [1,2].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] E. Atherton, et al. (1980) J. Chem. Soc., Chem. Commun., 970.
[2] D. A. Stetsenko & M. J. Gait (2001) Bioconjugate Chem., 12, 576.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 97 %
Purity (TLC(0811)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1083

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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