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8.52059

Fmoc-Hse(Trt)-OH

Novabiochem®

Synonym(s):

Fmoc-Hse(Trt)-OH, N-α-Fmoc-O-trityl-L-homoserine

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About This Item

Empirical Formula (Hill Notation):
C38H33NO5
CAS Number:
111061-55-3
Molecular Weight:
583.67
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
MFCD00270544
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Quality Level

200

product line

Novabiochem®

assay

≥80.0% (acidimetric), ≥98% (TLC), ≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

hydroxyl

storage temp.

15-25°C

SMILES string

N([C@@H](CCOC(c6ccccc6)(c5ccccc5)c4ccccc4)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C38H33NO5/c40-36(41)35(39-37(42)43-26-34-32-22-12-10-20-30(32)31-21-11-13-23-33(31)34)24-25-44-38(27-14-4-1-5-15-27,28-16-6-2-7-17-28)29-18-8-3-9-19-29/h1-23,34-35H,24-26H2,(H,39,42)(H,40,41)/t35-/m0/s1

InChI key

QUTREFXHXPNEJN-DHUJRADRSA-N

General description

Building block which enables side-chain modification of homoserine serines by Fmoc SPPS. The Trt group can be removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This derivative has been employed to prepare oligonucleotide conjugates [1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

[1] D. A. Stetsenko & M. J. Gait (2001) Bioconjugate Chem. , 12, 576.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 80.0 %
Water (K. F.): ≤ 1.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1126

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Articles

Selecting Orthogonal Building Blocks

Novabiochem® offers orthogonally protected amino acids for peptide synthesis, including cyclic and branched peptides.