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8.52109

Fmoc-Gly-(Dmb)Gly-OH

Name: Fmoc-Gly-(Dmb)Gly-OH
Brand: MM

≥98% (TLC), for peptide synthesis, Novabiochem^®

Synonym(s):

Fmoc-Gly-(Dmb)Gly-OH, N-α-Fmoc-L-glycyl-N-α-(2, 4-dimethoxybenzyl)-glycine

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₈N₂O₇

CAS Number:

848861-65-4

Molecular Weight:

504.53

MDL number:

MFCD08064315

UNSPSC Code:

12352209

NACRES:

NA.22

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Properties

Product Name

Fmoc-Gly-(Dmb)Gly-OH, Novabiochem^®

Quality Segment

200

product line

Novabiochem^®

assay

≥90.0% (acidimetric), ≥95.0% (HPLC), ≥98% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

SMILES string

N(Cc4c(cc(cc4)OC)OC)(CC(=O)O)C(=O)CNC(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C28H28N2O7/c1-35-19-12-11-18(25(13-19)36-2)15-30(16-27(32)33)26(31)14-29-28(34)37-17-24-22-9-5-3-7-20(22)21-8-4-6-10-23(21)24/h3-13,24H,14-17H2,1-2H3,(H,29,34)(H,32,33)

InChI key

NJUCBQMDTSVIGD-UHFFFAOYSA-N

Description

General description

The use of this derivative was found to be essential for the synthesis of peptides related to nucleolin^[1]. Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP^®/DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

^[1] S. Zahariev, et al. (2005) J. Pept. Sci., 11, 17.

Analysis Note

Color (visual): white to slight yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1266

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c