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Merck

8.52224

Fmoc-Leu-OPfp

Novabiochem®

Synonym(s):

Fmoc-Leu-OPfp, N-α-Fmoc-L-leucine pentafluorophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C27H22F5NO4
CAS Number:
Molecular Weight:
519.46
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
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Quality Level

product line

Novabiochem®

assay

≥97.5% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

101-115 °C

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

SMILES string

Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)CC(C)C)F)F

InChI

1S/C27H22F5NO4/c1-13(2)11-19(26(34)37-25-23(31)21(29)20(28)22(30)24(25)32)33-27(35)36-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,33,35)/t19-/m0/s1

InChI key

NTQJCLLWLHKJLU-IBGZPJMESA-N

General description

Pre-formed pentafluorophenyl ester for coupling of leucine amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): -27.5 - -22.5 °
DCU (DC (0003)): ≤ 2 %
Solubility (0.5 mmole in 3 ml DMF): clearly soluble
Assay (HPLC, area%): ≥ 97.5 % (a/a)

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1510

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3



Certificates of Analysis (COA)

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