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Merck

8.52366

Fmoc-Thr(tBu)-OPfp

Novabiochem®

Synonym(s):

Fmoc-Thr(tBu)-OPfp, N-α-Fmoc-O-t.-butyl-L-threonine pentafluorophenyl ester

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About This Item

Empirical Formula (Hill Notation):
C29H26F5NO5
CAS Number:
Molecular Weight:
563.51
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
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Quality Level

product line

Novabiochem®

assay

≥98.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

hydroxyl

storage temp.

15-25°C

SMILES string

Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC2c3c(cccc3)c4c2cccc4)[C@H](OC(C)(C)C)C)F)F

InChI

1S/C29H26F5NO5/c1-14(40-29(2,3)4)25(27(36)39-26-23(33)21(31)20(30)22(32)24(26)34)35-28(37)38-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19,25H,13H2,1-4H3,(H,35,37)/t14-,25+/m1/s1

InChI key

BHUUPIXJXWQAMT-PWECECGKSA-N

General description

Pre-formed pentafluorophenyl ester for coupling of threonine amino-acid residues by Fmoc SPPS. Use enables bromophenol blue monitoring of amide bond formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Analysis Note

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 98.0% (a/a)
Purity (TLC (0004)): <2% DCU
Assay (HPLC, area%): ≥ 98.0% (a/a)
Solubility (1 mmol in 6 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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