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8.52371

Fmoc-His(Clt)-OH

for peptide synthesis, Novabiochem

Synonym(s):

Fmoc-His(Clt)-OH, N-α-Fmoc-N-im-2-chlorotrityl-L-histidine

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About This Item

Empirical Formula (Hill Notation):
C40H32ClN3O4
CAS Number:
224032-19-3
Molecular Weight:
654.15
UNSPSC Code:
12352209
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Product Name

Fmoc-His(Clt)-OH, Novabiochem®

product line

Novabiochem®

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

InChI

1S/C40H32ClN3O4/c41-36-22-12-11-21-35(36)40(27-13-3-1-4-14-27,28-15-5-2-6-16-28)44-24-29(42-26-44)23-37(38(45)46)43-39(47)48-25-34-32-19-9-7-17-30(32)31-18-8-10-20-33(31)34/h1-22,24,26,34,37H,23,25H2,(H,43,47)(H,45,46)/t37-/m0/s1

InChI key

SYGADBVEKBWUKO-QNGWXLTQSA-N

General description

A useful derivative for the convergent synthesis of peptide due to the enhanced stability of Clt group compared to Trt group to mildy acidic reagents. Fmoc-His-(Clt)-OH gives approximately a third less racemization when compared to Fmoc-His(Trt)-OH during slow coupling reactions.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_c

Not applicable

Certificates of Analysis (COA)

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