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Merck

8.52412

Fmoc-His(MBom)-OH

N-α-Fmoc-3-methoxybenzyloxymethyl-L-histidine Novabiochem®

Synonym(s):

Fmoc-His(MBom)-OH, N-α-Fmoc-N-π-(p-methoxybenzyloxymethyl)-L-histidine

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About This Item

Empirical Formula (Hill Notation):
C30H29N3O6
Molecular Weight:
527.57
UNSPSC Code:
12352209

Product Name

Fmoc-His(MBom)-OH, N-α-Fmoc-3-methoxybenzyloxymethyl-L-histidine Novabiochem®

product line

Novabiochem®

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

15-25°C

Quality Level

200

Related Categories

Analysis Note

Colour (visual): white to off white
Appearance of substance (visual): powder
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (DC(BAWO)): ≥ 98 %
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clear soluble
Enantiomeric purity: ≥ 99.5 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

General description

A novel histidine derivative for Fmoc SPPS in which the π-imidazole nitrogen is blocked with the acid-labile MBom group, In contrast to Fmoc-His(Trt)-OH, coupling of this derivative is free from the risk of racemization, even under base-mediated coupling conditions. Methoxyamine should be added to the cleavage mixture to scavenge liberated formaldehyde.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] H. Hibino et al. (2011) Tetrahedron lett., 52, 4947.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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