8.52412
Fmoc-His(MBom)-OH
N-α-Fmoc-3-methoxybenzyloxymethyl-L-histidine Novabiochem®
Synonym(s):
Fmoc-His(MBom)-OH, N-α-Fmoc-N-π-(p-methoxybenzyloxymethyl)-L-histidine
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About This Item
Empirical Formula (Hill Notation):
C30H29N3O6
Molecular Weight:
527.57
UNSPSC Code:
12352209
Quality Level
product line
Novabiochem®
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
15-25°C
General description
A novel histidine derivative for Fmoc SPPS in which the π-imidazole nitrogen is blocked with the acid-labile MBom group, In contrast to Fmoc-His(Trt)-OH, coupling of this derivative is free from the risk of racemization, even under base-mediated coupling conditions. Methoxyamine should be added to the cleavage mixture to scavenge liberated formaldehyde.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] H. Hibino et al. (2011) Tetrahedron lett., 52, 4947.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references
[1] H. Hibino et al. (2011) Tetrahedron lett., 52, 4947.
Analysis Note
Colour (visual): white to off white
Appearance of substance (visual): powder
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (DC(BAWO)): ≥ 98 %
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clear soluble
Enantiomeric purity: ≥ 99.5 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Purity (HPLC): ≥ 98.0 % (a/a)
Purity (DC(BAWO)): ≥ 98 %
Identity (IR): passes test
Solubility (1 mmole in 2 ml DMF): clear soluble
Enantiomeric purity: ≥ 99.5 % (a/a)
Ethyl acetate (HS-GC): ≤ 0.5 %
Acetate (IC): ≤ 0.1 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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