8.55013
NovaSyn®TG Sieber resin
Novabiochem®
Synonym(s):
9-Fmoc-amino-xanthen-3-yloxy TG resin
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About This Item
NACRES:
NA.22
UNSPSC Code:
13111023
Quality Segment
product line
NovaSyn® TG, Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
2-8°C
General description
NovaSyn TG Sieber resin consists of 130 μm NovaSyn TG bromo resin derivatized with Sieber′s xanhydrylamine linker [1,2]. This resin is ideal for the Fmoc SPPS of partially protected peptide amide fragments. Cleavage from this support is effected by treatment with 1% TFA in DCM, conditions that leave most standard side-chain protecting groups intact. This resin can be reductively alkylated and used to prepare secondary carboxamides [3]. It can also be employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester [4].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198.
[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] P. Sieber (1987) Tetrahedron Lett., 28, 2107.
[2] C. Somlai, et al. in ′Peptides 1992, Proc.22nd European Peptide Symposium′, C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 198.
[3] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 1475.
[4] W. C. Chan, et al. (1995) J. Chem. Soc., Chem. Commun., 589.
Analysis Note
Color (visual): light yellow to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.10 - 0.25 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is NovaSyn TG resin (130µm)
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.10 - 0.25 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is NovaSyn TG resin (130µm)
Other Notes
Replaces: 01-64-0092
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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