8.55053
Dnp NovaTag® resin
Novabiochem®
Synonym(s):
N-Dnp-NÆ-Fmoc-ethylenediamine MPB-AM resin
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Quality Level
product line
NovaSyn® TG, Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
15-25°C
General description
Dnp NovaTag resin is an ideal tool for the synthesis of FRET peptide substrates based on the 7-methoxycoumarin (Mca) and 2,4-dintrophenyl (Dnp) fluorophore/quench pair. The resin pre-loaded with the Dnp quencher group can be used directly in Fmoc SPPS. Following peptide assembly, the Mca group is coupled to the N-terminal N-amino group using Mca-OSu, or introduced to a side-chain of Lys using Fmoc-Lys(Mca)-OH, to give after TFA cleavage the desired FRET peptide substrate.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Analysis Note
Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.30 - 0.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly styrene - 1 % DVB 100 - 200 mesh
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.30 - 0.60 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly styrene - 1 % DVB 100 - 200 mesh
Other Notes
Replaces: 04-12-3903
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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