8.55140
Fmoc-PAL-Linker
Novabiochem®
Synonym(s):
Fmoc-PAL-Linker
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About This Item
Empirical Formula (Hill Notation):
C29H31NO7
CAS Number:
Molecular Weight:
505.56
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
Quality Level
product line
Novabiochem®
form
solid
reaction suitability
reagent type: linker
manufacturer/tradename
Novabiochem®
mp
178-180 °C
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
SMILES string
N(Cc4c(cc(cc4OC)OCCCCC(=O)O)OC)C(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C29H31NO7/c1-34-26-15-19(36-14-8-7-13-28(31)32)16-27(35-2)24(26)17-30-29(33)37-18-25-22-11-5-3-9-20(22)21-10-4-6-12-23(21)25/h3-6,9-12,15-16,25H,7-8,13-14,17-18H2,1-2H3,(H,30,33)(H,31,32)
InChI key
ATYUCXIJDKHOPX-UHFFFAOYSA-N
General description
Barany′s aminomethyl-dimethoxyphenoxyvaleric acid linker . The amino group of this linker can be easily acylated under standard coupling conditions. Following peptide assembly, treatment with 95% TFA containing scavengers releases the desired peptide amide. Studies have shown the acid sensitivity of this linker to be around twice that of the Rink amide linker. There is some evidence to suggest that PAL resins give greater yields in microwave assisted synthesis.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Analysis Note
Color (visual): white to beige to grey
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(0811)): ≥ 98.0 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
To see the solvent systems used for TLC of Novabiochem® products please click here.
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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