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8.56186

Fmoc-Lys(ivDde)-Wang resin (100-200 mesh)

Novabiochem®

Synonym(s):

Fmoc-Protected Lysine Resin

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About This Item

NACRES:
NA.22
UNSPSC Code:
12352209
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Quality Segment

200

form

beads

manufacturer/tradename

Novabiochem®

functional group

Fmoc

storage temp.

2-8°C

General description

Useful tool for the synthesis of side-chain modified, cyclic and branched peptides by Fmoc SPPS. Following chain extension, the side-chain ivDde group is removed with 2% hydrazine in DMF, enabling selective modification of the ε-lysine amino group.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
SelectingOrthogonal Building Blocks

Literature references:
[1] R. Chhabra, et al. (1998) Tetrahedron Lett., 39, 1603.

Application

Fmoc-Lys(ivDde)-Wang resin (100-200 mesh) has been used as a solid support to prepare a peptide bearing a hexacarbonyldiiron cluster, neoglycopeptides and lipopeptides as putative antifungal and cancer vaccines, respectively.

Analysis Note

Color (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene -1 % DVB), 100- 200 mesh.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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