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Key Documents

MAB342A4

Sigma-Aldrich

Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate

clone mGalC, from mouse, ALEXA FLUOR™ 488

Synonym(s):

Galactoceramide, Galactocerebroside, Galactosylceramide, GalC

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

mGalC, monoclonal

species reactivity

rabbit, rat

species reactivity (predicted by homology)

human, bovine (immunogen homology), chicken, mouse

technique(s)

immunocytochemistry: suitable

isotype

IgG3

shipped in

wet ice

target post-translational modification

unmodified

General description

Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage.

Application

Detect Galactocerebroside using this Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate validated for use in ICC.

Biochem/physiol Actions

This antibody recognizes Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold to a lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells.

Physical form

Purified mouse monoclonal IgG3 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

Analysis Note

Control
Rat oligodendrocyte cells
Evaluated by Immunocytochemistry in rat oligodendrocyte cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Galactocerebroside in rat oligodendrocyte cells. Performed without Triton.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Shun Yamamuro et al.
International journal of oncology, 47(5), 1647-1654 (2015-09-24)
Glioma stem-like cells (GSCs) are undifferentiated cells that are considered to be an origin of glioblastomas. Furthermore, they may contribute to treatment resistance and recurrence in glioblastomas. GSCs differentiate into differentiated glioma cells (non-glioma stem-like cells: non‑GSCs), and interconversion might
Juan F Reyes et al.
Glia, 62(3), 387-398 (2014-01-03)
The origin of α-synuclein (α-syn)-positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy (MSA) is enigmatic, given the fact that oligodendrocytes do not express α-syn mRNA. Recently, neuron-to-neuron transfer of α-syn was suggested to contribute to the pathogenesis
Hal X Nguyen et al.
The Journal of comparative neurology, 522(12), 2767-2783 (2014-04-10)
Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) can differentiate into many cell types and are important for regenerative medicine; however, further work is needed to reliably differentiate hESC and hiPSC into neural-restricted multipotent derivatives or specialized

Global Trade Item Number

SKUGTIN
MAB342A404053252647741

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