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Merck

MAB342A4

Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate

clone mGalC, from mouse, ALEXA FLUOR™ 488

Synonym(s):

Galactoceramide, Galactocerebroside, Galactosylceramide, GalC

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702

Product Name

Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate, clone mGalC, from mouse, ALEXA FLUOR™ 488

biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

mGalC, monoclonal

species reactivity

rabbit, rat

species reactivity (predicted by homology)

human, bovine (immunogen homology), chicken, mouse

technique(s)

immunocytochemistry: suitable

isotype

IgG3

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Legal Information

ALEXA FLUOR is a trademark of Life Technologies

Analysis Note

Control
Rat oligodendrocyte cells
Evaluated by Immunocytochemistry in rat oligodendrocyte cells.

Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Galactocerebroside in rat oligodendrocyte cells. Performed without Triton.

Application

Detect Galactocerebroside using this Anti-Galactocerebroside Antibody, clone mGalC, Alexa Fluor™488 Conjugate validated for use in ICC.

Biochem/physiol Actions

This antibody recognizes Galactocerebroside (GalC), sulfatide, psychosine and other galactolipids. Cross-reacts with the sulfatide ester of GalC, but to a 16-fold to a lesser extent. No cross-reactivity with sphingosine, ceramide, mixed ganglioside or glucocerebroside. Binds specifically with oligodendrocytes and Schwann cells.

General description

Galactocerebroside (GalC) is a major galactosphingolipid of myelin which plays a role in myelination. GalC is a very useful, specific marker for oligodendroglial lineage.

Physical form

Purified mouse monoclonal IgG3 conjugated to Alexa Fluor™ 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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International journal of oncology, 47(5), 1647-1654 (2015-09-24)
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Juan F Reyes et al.
Glia, 62(3), 387-398 (2014-01-03)
The origin of α-synuclein (α-syn)-positive glial cytoplasmic inclusions found in oligodendrocytes in multiple system atrophy (MSA) is enigmatic, given the fact that oligodendrocytes do not express α-syn mRNA. Recently, neuron-to-neuron transfer of α-syn was suggested to contribute to the pathogenesis
Hal X Nguyen et al.
The Journal of comparative neurology, 522(12), 2767-2783 (2014-04-10)
Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) can differentiate into many cell types and are important for regenerative medicine; however, further work is needed to reliably differentiate hESC and hiPSC into neural-restricted multipotent derivatives or specialized

Global Trade Item Number

SKUGTIN
MAB342A404053252647741

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