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MABC543

Sigma-Aldrich

Anti-FBPase 1, clone 13A8.1 Antibody

clone 13A8.1, from mouse

Synonym(s):

Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

13A8.1, monoclonal

species reactivity

mouse, human

technique(s)

immunohistochemistry: suitable (paraffin)
western blot: suitable

isotype

IgMκ

NCBI accession no.

NP_000498

UniProt accession no.

P09467

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FBP1(2203)

General description

Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets.
~36 kDa observed. Uncharacterized band(s) may appear in some lysates.

Immunogen

KLH-conjugated linear peptide corresponding to human FBPase 1.

Application

Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue.

Physical form

Format: Purified

Analysis Note

Evaluated by Western Blotting in mouse stomach tissue lysate.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.

Other Notes

Concentration: Please refer to lot specific datasheet.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Lucia Carolina Leal-Esteban et al.
PLoS genetics, 14(7), e1007487-e1007487 (2018-07-12)
Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). Here, we found

Global Trade Item Number

SKUGTIN
MABC54304055977123838

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