MABC543
Anti-FBPase 1, clone 13A8.1 Antibody
clone 13A8.1, from mouse
Synonym(s):
Fructose-1,6-bisphosphatase 1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
13A8.1, monoclonal
Application:
IHC, WB
Citations:
1
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
13A8.1, monoclonal
species reactivity
mouse, human
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... FBP1(2203)
General description
Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets.
~36 kDa observed. Uncharacterized band(s) may appear in some lysates.
Immunogen
KLH-conjugated linear peptide corresponding to human FBPase 1.
Application
Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue.
Physical form
Format: Purified
Analysis Note
Evaluated by Western Blotting in mouse stomach tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.
Other Notes
Concentration: Please refer to lot specific datasheet.
Still not finding the right product?
Try our Product Selector Tool to narrow your options
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Lucia Carolina Leal-Esteban et al.
PLoS genetics, 14(7), e1007487-e1007487 (2018-07-12)
Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). Here, we found
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABC543 | 04055977123838 |